[{"@context":"https:\/\/schema.org\/","@type":"Article","@id":"https:\/\/protocz.cz\/depresivni-porucha\/#Article","mainEntityOfPage":"https:\/\/protocz.cz\/depresivni-porucha\/","headline":"Depresivn\u00ed porucha","name":"Depresivn\u00ed porucha","description":"Antidepresiva jsou v\u00a0dne\u0161n\u00ed dob\u011b jednou z\u00a0nejvyu\u017e\u00edvan\u011bj\u0161\u00edch l\u00e9kov\u00fdch skupin. Je to pr\u00e1v\u011b proto, \u017ee se dnes zvy\u0161uje v\u00fdskyt \u00fazkost\u00ed, depresivn\u00edch poruch a poruch n\u00e1lady, na kter\u00e9 se tyto l\u00e9ky obvykle vyu\u017e\u00edvaj\u00ed. Krom\u011b t\u00e9to indikace se mohou ale pou\u017e\u00edt i na dal\u0161\u00ed diagn\u00f3zy, kter\u00e9 s\u00a0psychiatri\u00ed nemus\u00ed m\u00edt nic spole\u010dn\u00e9ho. Jak\u00e9 vlastn\u011b existuj\u00ed typy t\u011bchto l\u00e9\u010div? Jako prvn\u00ed […]","datePublished":"2023-08-23","dateModified":"2023-08-23","author":{"@type":"Person","@id":"https:\/\/protocz.cz\/author\/#Person","name":"","url":"https:\/\/protocz.cz\/author\/","identifier":1,"image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/2d2e3fdaba6370eba756fb4048c695326686ff29010a0df4d58b27c20544521d?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/2d2e3fdaba6370eba756fb4048c695326686ff29010a0df4d58b27c20544521d?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"protocz.cz","logo":{"@type":"ImageObject","@id":"\/logo.png","url":"\/logo.png","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/protocz.cz\/wp-content\/uploads\/medications-1853400_640(1).jpg","url":"https:\/\/protocz.cz\/wp-content\/uploads\/medications-1853400_640(1).jpg","height":0,"width":0},"url":"https:\/\/protocz.cz\/depresivni-porucha\/","about":["Zdrav\u00ed"],"wordCount":339,"articleBody":"Antidepresiva jsou v\u00a0dne\u0161n\u00ed dob\u011b jednou z\u00a0nejvyu\u017e\u00edvan\u011bj\u0161\u00edch l\u00e9kov\u00fdch skupin. Je to pr\u00e1v\u011b proto, \u017ee se dnes zvy\u0161uje v\u00fdskyt \u00fazkost\u00ed, depresivn\u00edch poruch a poruch n\u00e1lady, na kter\u00e9 se tyto l\u00e9ky obvykle vyu\u017e\u00edvaj\u00ed. Krom\u011b t\u00e9to indikace se mohou ale pou\u017e\u00edt i na dal\u0161\u00ed diagn\u00f3zy, kter\u00e9 s\u00a0psychiatri\u00ed nemus\u00ed m\u00edt nic spole\u010dn\u00e9ho. Jak\u00e9 vlastn\u011b existuj\u00ed typy t\u011bchto l\u00e9\u010div? Jako prvn\u00ed bychom mohli popsat SSRI, tedy l\u00e1tky, kter\u00e9 inhibuj\u00ed zp\u011btn\u011b vychyt\u00e1v\u00e1n\u00ed serotoninu ze synaptick\u00e9 \u0161t\u011brbiny. Nedostatek serotoninu je pravd\u011bpodobn\u011b d\u016fle\u017eit\u00fd mechanismus, kter\u00fd zp\u016fsobuje vznik deprese, tak\u017ee, pokud jeho mno\u017estv\u00ed zv\u00fd\u0161\u00edme, m\u016f\u017eeme se zbavit projev\u016f deprese. Do t\u00e9to skupiny pat\u0159\u00ed sertralin, fluoxetin, fluvoxamin a dal\u0161\u00ed. Jako druh\u00e1 jsou nejzn\u00e1m\u011bj\u0161\u00ed tricyklick\u00e1 antidepresiva, ta maj\u00ed n\u011bkolik mechanism\u016f \u00fa\u010dinku a s\u00a0t\u00edm tak\u00e9 souvis\u00ed vy\u0161\u0161\u00ed v\u00fdskyt ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f. Sem m\u016f\u017eeme zapo\u010d\u00edtat t\u0159eba imipramin, desipramin a amitriptylin. Krom\u011b serotoninu se pak v\u00a0patogenezi deprese objevuje tak\u00e9 nedostatek noradrenalinu, proto existuje dal\u0161\u00ed skupina, kter\u00e1 br\u00e1n\u00ed vychyt\u00e1v\u00e1n\u00ed obou l\u00e1tek (SNRI). Tady m\u016f\u017eeme zm\u00ednit velafaxin nebo duloxetin. Pokud by n\u011bkter\u00fd z\u00a0pacient\u016f neodpov\u00eddal ani na jeden druh antidepresiv, pak m\u016f\u017eeme vyzkou\u0161et, jestli u n\u011bj nen\u00ed hlavn\u00edm mechanismem nedostatek pouze noradrenalinu, pak pou\u017eijeme n\u011bkter\u00e9 z\u00a0l\u00e9\u010div jako bupropion, reboxetin nebo maprotiline. Speci\u00e1ln\u00edmi slo\u017eit\u011bj\u0161\u00edmi mechanismy pak p\u016fsob\u00ed t\u0159i l\u00e9\u010diva mirtazapin, trazodon a mianserin. D\u00e1le pak m\u016f\u017eeme p\u016fsobit na enzymy, kter\u00e9 ni\u010d\u00ed vyplaven\u00fd noradrenalin do synaptick\u00e9 \u0161t\u011brbiny. Pokud je inhibujeme, pak jej nem\u00e1 kdo odstra\u0148ovat a jeho mno\u017estv\u00ed se op\u011bt zv\u00fd\u0161\u00ed. V\u00a0tomto p\u0159\u00edpad\u011b m\u016f\u017eeme narazit na phenelzin, moclobemid nebo tranycypromin. Depresivn\u00ed porucha je v\u00e1\u017en\u00e9 onemocn\u011bn\u00ed, u kter\u00e9ho se pacietni mohou pokusit i o sebevra\u017edu, proto nen\u00ed vhodn\u00e9 tuto nemoc podce\u0148ovat.                                                                                                                                                                                                                                                                                                                                                                                                "},{"@context":"https:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Depresivn\u00ed porucha","item":"https:\/\/protocz.cz\/depresivni-porucha\/#breadcrumbitem"}]}]